About ZOVIRAX Cream


ZOVIRAX Cream is a prescription-strength cream that is applied directly to the cold sore. It contains an antiviral medication that stops the cold sore virus from multiplying. By fighting the virus itself, ZOVIRAX Cream helps speed healing when applied immediately upon noticing the first symptoms of a cold sore, so you can get back to feeling like yourself.

ZOVIRAX Cream should not be used in your eyes, mouth, nose or on your genitals.

How can ZOVIRAX Cream help?

ZOVIRAX Cream is a targeted topical antiviral treatment that, when used at the first sign of an outbreak, is clinically proven to:



Always have your ZOVIRAX Cream on hand to treat a cold sore outbreak when you feel it starting.

The most common skin-related side effects of ZOVIRAX Cream are dry or cracked lips, flakiness or dryness of skin, a burning or stinging feeling, or itching of the skin.


ZOVIRAX Cream is a cream applied directly to the cold sore itself. Use ZOVIRAX Cream as soon as you feel the first signs of a cold sore, such as itching, redness, burning or tingling, or when the cold sore appears. This helps ensure you get the most out of your treatment with ZOVIRAX Cream. ZOVIRAX Cream should be used 5 times a day for 4 days.

How to use ZOVIRAX Cream: DO's and DON'Ts

  • Use ZOVIRAX Cream at the first signs of a cold sore (itching, redness, burning, tingling) or when you see a cold sore.
  • Wash your hands with soap and water before and after application.
  • Ensure the affected area is clean and dry before application.
  • Apply ZOVIRAX Cream to the affected area 5X each day for 4 days, including the outer edge.
  • Always have ZOVIRAX Cream on hand so you can be ready to treat at the first signs of a cold sore.
  • Use ZOVIRAX Cream as your healthcare provider instructs you. If you have any side effects that bother you, stop treatment and talk to your doctor.
  • DON'T apply other skin products to the affected area during treatment.
  • DON'T rub the cold sore, as this may cause it to spread to other areas of your mouth or make your cold sore worse.
  • DON'T stop treatment early.
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ZOVIRAX Cream did not prevent the development of cold sore lesions.


ZOVIRAX Cream is a prescription medicine that is used to treat cold sores on the lips and around the mouth only, in patients 12 and older with normal immune systems.

ZOVIRAX Cream is not a cure for cold sores.

Important Safety Information

Do not use ZOVIRAX Cream if you are allergic to Zovirax Cream, acyclovir, valacyclovir, or any of its ingredients. ZOVIRAX Cream is most effective when used early, at the start of a cold sore. For best results, apply the cream at the first sign of a cold sore (such as tingling, redness, bump, or itch).

Use ZOVIRAX Cream only on your affected skin. Do not swallow ZOVIRAX Cream or apply it to the eyes, inside the mouth or nose, or on the genitals. Do not apply other topical products to the affected area while using ZOVIRAX Cream.

Before you start using ZOVIRAX Cream, tell your healthcare provider about any medications you are taking and any medical conditions you have, including if you become sick very easily (have a weak immune system), are pregnant, planning to become pregnant, or are breast feeding. You should not breastfeed if you have a cold sore near or on your breast.

The most common skin-related side effects of ZOVIRAX Cream are dry or cracked lips, flakiness or dryness of skin, a burning or stinging feeling, or itching of the skin.

You are encouraged to report side effects to FDA. Visit fda.gov/medwatch.com or call 1-800-FDA-1088.

Click here for Prescribing Information.

*This offer is only valid for patients with commercial insurance. Eligible uninsured patients will pay more. This offer is not valid for any person eligible for reimbursement of prescriptions, in whole or in part, by any federal, state, or other governmental programs, including, but not limited to, Medicare (including Medicare Advantage and Part A, B, and D plans), Medicaid, TRICARE, Veterans Administration or Department of Defense health coverage, CHAMPUS, the Puerto Rico Government Health Insurance Plan, or any other federal or state health care programs. This offer is good only in the U.S. at retail pharmacies owned and operated by Walgreen Co. (or its affiliates) or other participating independent retail pharmacies. This offer is not valid in Massachusetts or Minnesota or where otherwise prohibited, taxed or otherwise restricted. Click here for other terms and conditions that apply.